<img height="1" width="1" src="https://www.facebook.com/tr?id=1124406241028611&amp;ev=PageView &amp;noscript=1">
27122
Ezra Home Care: Unwavering Support for Israel Against Hamas Terrorism and Its Backers
phone
617-527-9000
mail
info@ezrahomecare.com
facebook twitter linkedin

Is ALS Genetic?

Amyotrophic lateral sclerosis (ALS) has been the object of medical research for many years. One of the most frequently asked questions concerning this disease is whether ALS is genetic. This article will discuss the possible genetic components of ALS. 

Familial vs. Sporadic ALS

ALS can be broadly classified into two categories based on its origin: familial ALS (FALS) and sporadic ALS (SALS).

  • Familial ALS: About 5-10% of all ALS cases are familial. In these cases, the disease runs in families and is caused by mutations in specific genes, and carried on. If one family member is diagnosed with FALS, the risk of other family members developing the disease significantly increases.
  • Sporadic ALS: About 90-95% of ALS cases are sporadic. This means that they occur randomly without any clear familial pattern. While the exact cause of SALS is still not entirely known, current research has suggested that its etiology lies somewhere in a combination of genetic and environmental factors. 

The Role of Genetics

Genetic mapping has identified multiple genes concerning FALS. Some of the most significant include:

  1. C9ORF72: A mutation in this gene is the most common genetic cause of FALS and is found in about 25-40% of familial cases.
  2. SOD1: Mutations in the SOD1 gene account for around 20% of FALS cases.
  3. TARDBP and FUS: These genes are less commonly associated with FALS but have been identified in a smaller percentage of patients.

Some research has shown that these mutations are not only linked to FALS, as they have also been found in a very small number of SALS patients, suggesting that genetics can play a role even in sporadic cases.

Genetic Testing and Counseling

Families with a history of ALS are suggested to undergo genetic testing to identify known ALS-associated mutations. 

 It's crucial to undergo genetic counseling before and after testing to understand the potential results. 

While a portion of ALS cases are genetic, particularly in familial instances, the majority of cases are sporadic and may arise from a combination of several factors. You can read more about the possible causes of ALS here

Credits:
Amyotrophic Lateral Sclerosis (ALS)
C9ORF72: What It Is, What It Does, and Why It Matters
SOD1 in ALS: Taking Stock in Pathogenic Mechanisms and the Role of Glial and Muscle Cells
TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis

Founded in 2008, Ezra Home Care offers live-in home care, 24-hour care, and hourly senior care.
All our caregivers are state-certified and provide services like personal carehousekeepingcompanionship, help with medication, and transportation assistance. We've spent 15 years refining our caregiver selection process to ensure families' peace of mind. Reach out for details and quotes.

Contact Us

or call us at 617-527-9000

You may also like to read
Alexander Schechter May 16, 2024
​​Is Dementia Hereditary?

Dementia is a complex disease that affects both the patient’s and the family’s well-being. It is a condition that is difficult to deal with, which is why a lot of people would be curious to know if dementia is a problem that can be inherited from the parent to a child. 

Read More
pca vs cna vs hha
Alexander Schechter Apr 29, 2024
Understanding Differences Between PCAs, HHAs and CNAs

Family members can be overwhelmed when entering a completely new world of caregiving, and being faced with a load of unknown acronyms such as PCA, HHA, and CNA does not help. If you're considering hiring a caregiver for your loved one and struggling with these unfamiliar terms, this article might be for you. 

Read More
Is Palliative Care The Same as End-of-Life Care?
Alexander Schechter Jan 26, 2024
Is Palliative Care The Same as End-of-Life Care?

It is important to understand what are the differences between different forms of late-stage care when dealing with a serious and terminal disease. Let's discuss the specifics of palliative and end-of-life care to help you make informed decisions when the time comes. 

Read More
Most popular posts